F. Poggio, M. Brofiga, M. Tedesco, P. Massobrio, E. Adriano, M. Balestrino. Lack of epileptogenic effects of the creatine precursor guanidinoacetic acid on neuronal cultures in vitro. Biomolecules, Vol. 13, N. 1, doi: 10.3390/biom13010074, 2023 .

G. Biella, F. Callegari, A.N. Castagno, P.W. Cattaneo, J. Cazzola, I. Cristiani, M. Grassi, P. Malcovati, P. Massobrio, P. Minzioni, M.C. Prata, S. Ramat,A. Rappoldi, M. Rossella, P. Spaiardi, F. Talpo. Visual prostheses based on Silicon PhotoMultiplier: The SPEye project. Nuclear Instruments and Methods in Physics Research A, Vol. 1048, doi: 10.1016/j.nima.2022.167935, 2023.


F. Callegari*, M. Brofiga*, F. Poggio, P. Massobrio. Stimulus-evoked activity modulation of in vitro engineered cortical and hippocampal networks, Micromachines, doi: 10.3390/mi13081212, 2022.  (*equal contribution).

I. Demori, G. Giordano, V. Mucci, S. Losacco, L. Marinelli, P. Massobrio, F. Blanchini, B. Burlando. Thalamocortical bistable switch as a theoretical model of fibromyalgia pathogenesis inferred from a literature survey, Journal of Computational Neuroscience, doi: 10.1007/s10827-022-00826-82022, 2022.

L. Ermini, P. Massobrio, L. Mesin. Approximate entropy of spiking series reveals different dynamical states in cortical assemblies, Electronics, doi: 10.3390/electronics11060936, 2022.

M. Brofiga, P. Massobrio. Brain-on-a-chip: dream or reality?, Frontiers in Neuroscience, doi: 10.3389/fnins.2022.837623, 2022.

M. Brofiga, M. Pisano, M. Tedesco, A. Boccaccio, P. Massobrio. Functional inhibitory connections modulate the electrophysiological activity patterns of cortical-hippocampal ensembles. Cerebral Cortex, Vol. 32, pp. 1866-1881, doi: 10.1093/cercor/bhab318, 2022.


M. Brofiga, M. Pisano, R. Raiteri, P. Massobrio. On the road to the brain-on-a-chip. A review on strategies, methods, and applications. Journal of Neural Engineering, Vol. 18, doi: 10.1088/1741-2552/ac15e4, 2021.

A. Boschi*, M. Brofiga*, P. MassobrioThresholding functional connectivity matrices to recover the topological properties of large-scale neuronal networks. Frontiers in Neuroscience, doi:  10.3389/fnins.2021.705103, 2021.  (*equal contribution).

M. Brofiga, M. Pisano, F. Callegari, P. Massobrio. Exploring the contribution of thalamic and hippocampal input on cortical dynamics in a brain-on-a-chip model. IEEE Transactions on Medical Robotics and Bionics, Vol. 3, doi: 10.1109/tmrb.2021.3072234, 2021.

M. Brofiga*, M. Pisano*, M. Tedesco, R. Raiteri, P. Massobrio. Three-dimensionality Shapes the Dynamics of Cortical Interconnected to Hippocampal Networks. Journal of Neural Engineering, Vol. 17, doi: 10.1088/1741-2552/aaa140, 2020.  (*equal contribution).


S. Buccelli, Y. Bornat, I. Colombi, M. Ambroise, L. Martines, V. Pasquale, M. Bisio, J. Tessadori, P. Nowak, F. Grassia, A. Averna, M. Tedesco, P. Bonifazi, F. Difato, P. Massobrio, T. Levi, M. Chiappalone. A neuromorphic prosthesis to restore communication in neuronal networks. iScience, Vol. 19, pp. 402-414, doi: 10.1016/j.isci.2019.07.046, 2019.


D. Poli, P. Massobrio. High-frequency stimulation promotes reshaping of the functional connections and synaptic plasticity in in vitro cortical networks. Physical Biology, doi: 10.1088/1478-3975/aae43e, 2018.

V. P. Pastore, P. Massobrio, A. Godjoski, S. Martinoia, Identification of excitatory-inhibitory links and network topology in large-scale neuronal assemblies from multi-electrode recordings. PLoS Computational Biology, doi: 10.1371/journal.pcbi.100638, 2018.

 C.C. Rojas, M. Tedesco, P. Massobrio, A. Marino, G. Ciofani, S. Martinoia, R. Raiteri. Acoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles. Journal of Neural Engineering, Vol. 15, N. 3, doi: 10.1088/1741-2552/aaa140, 2018.

M. Tedesco, D. Di Lisa, P. Massobrio, N. Colistra, M. Pesce, T. Catelani, E. Dellacasa, R. Raiteri, S. Martinoia, L. Pastorino. Soft chitosan microbeads scaffold for 3D functional neuronal networks. Biomaterials, Vol. 156, pp. 159-171, doi: 10.1016/j.biomaterials.2017.11.043, 2018.

T. Levi, P. Bonifazi, P. Massobrio, M. Chiappalone. Closed-loop systems for next-generation neuroprostheses. Frontiers in Neuroscience, doi: 10.3389/fnins.2018.00026, 2018.

V. P. Pastore, A. Godjoski, S. Martinoia, P. Massobrio. SpiCoDyn: a toolbox for the analysis of neuronal network dynamics and connectivity from multi-site spike signal recordings. Neuroinformatics, Vol. 16, No. 1, pp. 15-30, doi: 10.1007/s12021-017-9343-z, 2018.

 G. Massobrio, S. Martinoia, P. Massobrio. Equivalent circuit of the neuro-electronic junction for signal recordings from planar and engulfed micro- nano-electrodes. IEEE Transactions on Biomedical Circuits and System, Vol. 12, No. 1, pp. 3-12, doi: 10.1109/TBCAS.2017.2749451, 2018.


P. Balbi, P. Massobrio, J. Hellgren-Kotaleski. A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms. PLoS Computational Biology, Vol. 13, No. 9, pp. e1005737, doi: 10.1371/journal.pcbi.1005737, 2017.

D. Pani, P. Meloni, G. Tuveri, F. Palumbo, P. Massobrio, L. Raffo. An FPGA platform for real-time simulation of spiking neuronal networks. Frontiers in Neuroscience, Vol. 11, No. 90, doi: 10.3389/fnins.2017.00090, 2017.


P. Massobrio, G. Massobrio, S. Martinoia. Interfacing cultured neurons to microtransducers arrays: a review of the neuro-electronic junction models. Frontiers in Neuroscience, Vol. 10, No. 282, doi: 10.3389/fnins.2016.00282, 2016.

V. P. Pastore, D. Poli, A. Godjoski, S. Martinoia, P. Massobrio. ToolConnect: a functional connectivity toolbox for in vitro networks. Frontiers in Neuroinformatics, Vol. 10, No. 13, doi: 10.3389/fninf.2016.00013, 2016.

D. Poli, V. P. Pastore, S. Martinoia, P. Massobrio. From functional to structural connectivity using partial correlation in neuronal assemblies. Journal of Neural Engineering, Vol. 13, No. 2, 2016.


M. Tedesco, M. Frega, S. Martinoia, M. Pesce, P. Massobrio. Interfacing 3D engineered neuronal cultures to Micro-Electrode Arrays: an innovative in vitro experimental model, Journal of Visualized Experiments, No. 104, doi: 10.3791/53080, 2015.

D. Poli, V. P. Pastore, P. Massobrio. Functional connectivity in in vitro neuronal assemblies, Frontiers in Neural Circuits, Vol. 9, No. 57, doi: 10.3389/fncir.2015.00057, 2015.

P. Massobrio, V. Pasquale, S. Martinoia. Self-organized criticality in cortical assemblies occurs in concurrent scale-free and small-world networks, Scientific Reports, Vol. 5, No. 10578, doi: 10.1038/srep10578, 2015.

P. Massobrio, J. Tessadori, M. Chiappalone, M. Ghirardi, In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using Multi-Electrode Arrays (MEAs). Neural Plasticity, Vol. 2015, doi: 10.1155/2015/196195, 2015.

P. Massobrio, L. de Arcangelis, V. Pasquale, H. J. Jensen, D. Plenz. Criticality as a signature of healthy neural systems. Frontiers in Systems Neuroscience, Vol. 9, No. 22 doi: 10.3389/fnsys.2015.00022, 2015.

P. Balbi, S. Martinoia, P. Massobrio. Axon-somatic back-propagation in detailed models of spinal alpha motoneurons. Frontiers in Computational Neuroscience, Vol. 9, No. 15, doi: 10.3389/fncom.2015.00015, 2015.

V. Pirino, E. Riccomagno, S. Martinoia, P. Massobrio. A topological study of repetitive co-activation networks in in vitro cortical assemblies. Physical Biology, Vol. 12, No. 1, 2015.


M. Frega, M. Tedesco, P. Massobrio, M. Pesce, S. Martinoia. Network dynamics of 3D engineered neuronal cultures: a new experimental model for in-vitro electrophysiology. Scientific Reports, Vol. 4, N. 5489, doi: 10.1038/srep05489, 2014.

P. Balbi, S. Martinoia, R. Colombo, P. Massobrio. Modeling the spinal α-motoneuron recurrent discharge: a reappraisal of F wave. Clinical Neurophysiology, Vol. 125, No. 2, pp 427-429, 2014.


M. Mulas, P. Massobrio. NeuVision: a novel simulation environment to model spontaneous and stimulus-evoked activity of large-scale neuronal networks. Neurocomputing, Vol. 122, pp 441-457, 2013.

P. Bonifazi*, F. Difato*, P. Massobrio*, G. Breschi, V. Pasquale, T. Levi, M. Goldin, Y. Bornat, M. Tedesco, M. Bisio, S. Kanner, R. Galron, J. Tessadori, S. Taverna, M. Chiappalone. In vitro large-scale experimental and theoretical studies for the realization of bi-directional brain-prostheses. Frontiers in Neural Circuits, Vol. 7, No. 40, doi: 10.3389/fncir.2013.00040, 2013. (*equal contribution).

P. Massobrio, C. N. G. Giachello, M. Ghirardi, S. Martinoia. Selective modulation of chemical and electrical synapses of Helix neuronal networks during in vitro development. BMC Neuroscience, Vol. 14, No. 22, doi: 10.1186/1471-2202-14-22, 2013.


 T. Kanagasabapathi*, P. Massobrio*, R. A. Barone, M. Tedesco, S. Martinoia, W. J. Wadman, M. M. J. Decre. Functional connectivity and dynamics of cortical-thalamic networks co-cultured in a dual compartment device. Journal of Neural Engineering, doi: JNE/420796, 2012. (* equal contribution).


G. Massobrio, P. Massobrio, S. Martinoia. Investigation of extracellular signal shapes recorded by planar metal microelectrodes covered with carbon nanotubes: modeling and simulations. IEEE Transactions on Nanotechnology, Vol. 10, No. 6, pp. 1328- 1336, 2011.

28. G. Massobrio, A. Massobrio, L. Massobrio, P. Massobrio. Silicon-based biosensor functionalized with Carbon NanoTubes to investigate neuronal electrical activity in pH-stimulated environment: a modelling approach. Micro & Nano Letters, Vol. 6, No. 9, pp. 689-693, 2011.


M. Mulas, P. Massobrio, S. Martinoia, M. Chiappalone. A simulated neuro-robotic environment for bi-directional closed-loop experiments. Journal of Behavioral Robotics, Vol. 1, No., 3, pp. 179-186, 2010.


E. Bottino, P. Massobrio, S. Martinoia, G. Pruzzo, M. Valle. Low-noise low-power CMOS preamplifier for multisite extracellular neuronal recordings. Microelectronics Journal, Vol. 40, No. 12, pp. 1779-1787, 2009.

P. Massobrio, M. Tedesco, C. Giachello, M. Ghirardi, F. Fiumara, S. Martinoia. Helix neuronal ensembles with controlled cell type composition and placement develop functional polysynaptic circuits on Micro-Electrode Arrays, Neuroscience Letters, Vol. 467, No. 2, pp. 121-126, 2009.

M. Garofalo, T. Nieus, P. Massobrio, S. Martinoia. Evaluation of the performances of information theory-based methods and cross-correlation to estimate the functional connectivity in cultured cortical networks, PLoS ONE, Vol. 4, No. 8, pp. e6482, 2009.

L. Berdondini, P. Massobrio, M. Chiappalone, M. Tedesco, K. Imfeld, A. Maccione, M. Koudelka-Hep, S. Martinoia. Extracellular recordings from locally dense microelectrode arrays coupled to dissociated cortical cultures. Journal of Neuroscience Methods, Vol. 177, No. 2, pp. 386-396, 2009.

A. Maccione, M. Gandolfo, P. Massobrio, A. Novellino, S. Martinoia M. Chiappalone. A novel algorithm for precise identification of spikes in extracellularly recorded neuronal signals. Journal of Neuroscience Methods, Vol. 177, No. 1, pp. 241-249, 2009.


G. Massobrio, P. Massobrio, S. Martinoia. Modeling the neuron-carbon Nanotube-ISFET junction to investigate the electrophysiological neuronal activity. Nano Letters, Vol. 8, No. 12, pp. 4433-4440, 2008.

P. Massobrio, S. Martinoia. Modeling small-patterned neuronal networks coupled to Micro-Electrode Arrays. Journal of Neural Engineering, Vol. 5, No. 3, pp. 350-359, 2008.

M. Chiappalone, P. Massobrio, S. Martinoia. Network plasticity in cultured cortical assemblies. European Journal of Neuroscience, Vol. 28, No. 1, pp. 221-237, 2008.

V. Pasquale, P. Massobrio, L. L. Bologna, M. Chiappalone, S. Martinoia. Self-organization and neuronal avalanches in networks of dissociated cortical neurons. Neuroscience, Vol. 153, pp. 1354-1369, 2008.


G. Massobrio, P. Massobrio, S. Martinoia. Modeling and simulation of silicon neuron-to-ISFET junction. Journal of Computational Electronics, Vol. 6, No. 4, pp. 431-437, 2007.

P. Massobrio, G. Massobrio, S. Martinoia. Multi-program approach for simulating recorded extracellular signals generated by neurons coupled to microelectrode arrays. Neurocomputing, Vol. 70, pp. 2467-2476, 2007.

E. Macis, M. Tedesco, P. Massobrio, R. Raiteri, S. Martinoia. An automated micro-drop delivery system for neuronal network patterning on microelectrode arrays. Journal of Neuroscience Methods, Vol. 161, pp. 88-95, 2007.


S. Martinoia, P. Massobrio. ISFET-neuron junction: circuit models and extracellular signal simulations. Biosensors & Bioelectronics, Vol. 19, No. 11, pp. 1487-1496, 2004.

 S. Martinoia, P. Massobrio, M. Bove, G. Massobrio. Cultured neurons coupled to microelectrode arrays: circuit models, simulations and experimental data. IEEE Transactions on Biomedical Engineering, Vol. 51, No. 5, pp. 859-864, 2004.